Nash and his wife, Alicia, were traveling in a taxi on the New Jersey Turnpike in Middlesex County when it hit a guardrail, killing both at the scene, New Jersey State Police Sgt. Gregory Williams said Sunday morning.
The cab driver and a person in another car involved in the crash were brought to a nearby hospital with non-life threatening injuries, Williams said.
Actor Russell Crowe, who played Nash in the movie based on the 1998 biography, tweeted Sunday morning, "Stunned ... my heart goes out to John & Alicia & family. An amazing partnership. Beautiful minds, beautiful hearts."